EZH2 inhibitors and uses thereof
US11236082B2 · kind B2 · utility
0Cited by
6References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 6, 2015 |
| Grant date | Feb 1, 2022 |
| Priority date | — |
| Expiry date | Apr 24, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5008
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure provides compounds of any one of Formulae (I) and (II). The compounds described herein are inhibitors of histone methyltransferases (e.g., enhancer of zeste homolog 1 (EZH1) and enhancer of zeste homolog 2 (EZH2)) and are useful in treating and/or preventing a broad range of diseases (e.g., proliferative diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. Further provided in the present disclosure are methods of identifying EZH1 and/or EZH2 inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.