Antibodies to pyroglutamate amyloid-β and uses thereof

US11236155B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Bianca Van Broeck · Schilde, BE
• Marc Mercken · Turnhout, BE
• Wilson Edwards · Encinitas, US
• Sanjaya Singh · Sandy Hook, US
• Jinquan Luo · Malvern, US
• Sherry Lynn La Porte · Horsham, US
• Rajkumar Ganesan · Blue Bell, US
• Chichi Huang · Malvern, US

Key dates

• Filing date: Mar 25, 2020
• Grant date: Feb 1, 2022
• Expiry date: Mar 25, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides antibodies or antigen binding fragments thereof that bind to 3pE Aβ and methods of making and using the antibodies or antigen binding fragments thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other β-amyloid-related diseases.