Secretory immunoglobulin a (sIgA)-binding nucleic acid molecule, sIgA analysis sensor, and sIgA analysis method
US11236342B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Apr 20, 2017 |
| Grant date | Feb 1, 2022 |
| Priority date | — |
| Expiry date | Jan 29, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/336
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a novel molecule that can be used for detection of sIgA. The sIgA-binding nucleic acid molecule of the present invention is characterized in that it binds to secretory immunoglobulin A (sIgA) with a dissociation constant of 37.7 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 12 or a partial sequence thereof, for example. According to the sIgA-binding nucleic acid molecule of the present invention, it is possible to detect sIgA in saliva.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.