Method for screening drug and therapeutic targets used for treating Alzheimer's disease
US11236378B2 · kind B2 · utility
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Key dates
| Filing date | Apr 30, 2015 |
| Grant date | Feb 1, 2022 |
| Priority date | — |
| Expiry date | Nov 22, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed is the use of genetic means or a related inhibitor to inhibit and down-regulate the amount of PI4KIIIα protein, RBO/EFR3/EFR3A/EFR3B membrane proteins, TTC7 protein and membrane protein complexes formed by said proteins, or related enzyme activity to promote Aβ secretion by neuronal cells, reduce Aβ accumulation within neurons, and thereby reduce AD model fruit fly and mouse nerve dysfunction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.