Autophagy inducers for treatment of CNS conditions

US11241436B2 · kind B2 · utility

Assignees

• Northwestern University · US
• THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · US
• University of Kansas · US

Inventors

• Congcong He · Chicago, US
• Sui Huang · Chicago, US
• Chen Wang · Chicago, US
• Altea Rocchi · Evanston, US
• Juan Jose Marugan · Gaithersburg, US
• Marc Ferrer · Potomac, US
• Samarjit Patnaik · Gaithersburg, US
• Yuchi Chen · Rockville, US
• Kevin Frankowski · Lawrence, US
• Frank J. Schoenen · Lawrence, US

Key dates

• Filing date: Jan 25, 2018
• Grant date: Feb 8, 2022
• Expiry date: May 7, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.