Patent · US Active

Oxadiazole linkers and use thereof

US11241503B2 · kind B2 · utility

0Cited by

0References

57Claims

0Family size

Assignee

NewBio Therapeutics, Inc. · CN

Inventors

Nianhe Han · Newbury Park, US
Deqiang An · Shanghai, CN
Di Zeng · Shanghai, CN
Baoxiang Wang · Shanghai, CN
Huali Li · Shanghai, CN
Hang Chen · Boulder, US
Chun-Ying Yang · Taipei, TW

Key dates

Filing date	Jun 4, 2018
Grant date	Feb 8, 2022
Priority date	—
Expiry date	Dec 24, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed to oxadiazole linkers and use thereof, more specifically to the compounds represented by formula I, II, and III, and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I, II, and III is the same as that in the description.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.