Patent · US Active

Hydrophilic fluorinated molecules for liposomal 19F MRI probes with unique MR signatures

US11241510B2 · kind B2 · utility

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Key dates

Filing dateNov 30, 2017
Grant dateFeb 8, 2022
Priority date—
Expiry dateNov 30, 2037

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07B2200/05
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Readily available hydrophilic and small organofluorine moieties were condensed via “click chemistry” to generate nonionic hydrophilic fluorinated molecules with unique 19F MR signatures. These were used to fabricate stable liposome formulations for imaging various tissue types. This approach was tailored to exploit the broad spectrum of organic 19F molecular species and to generate probes with distinct 19F MRI signatures for simultaneous assessment of multiple molecular targets within the same target volume.

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