Minimally-invasive and activity-dependent control of excitable cells
US11242374B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 22, 2016 |
| Grant date | Feb 8, 2022 |
| Priority date | — |
| Expiry date | Jun 18, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14141
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of the invention can be used to desynchronize local activity of excitable cells in a mammalian tissue. The methods of the invention can be used to treat a disease or condition in a mammal, the disease or condition being related to bursting. The disease or condition can be Parkinson's disease, epilepsy, a sleep disorder, or a sensory-related disease or condition (e.g., attention deficit disorder or pain). The invention also provides a conjugate of containing a voltage-gated ion channel and a luminescent protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.