Antibodies against MICA and/or MICB and uses thereof

US11242393B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Michelle Renee KUHNE · San Francisco, US
• Alan J. Korman · Piedmont, US
• Haichun Huang · Fremont, US
• Yiming YIN · Andover, US
• Robert Graziano · Princeton, US
• Natalie Bezman · Foster City, US
• Pavel Strop · San Mateo, US
• Richard Y. Huang · Princeton, US
• Guodong Chen · East Brunswick Township, US
• Mohan Srinivasan · Cupertino, US
• Peter Sung Keun LEE · Millbrae, US
• Gamze Ozlem CAMDERE · Camarillo, US

Key dates

• Filing date: Mar 22, 2019
• Grant date: Feb 8, 2022
• Expiry date: Nov 28, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides antibodies that specifically bind human MICA/B and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an anti-MICA/B antibody.