Method for non-invasive prenatal diagnosis based on exosomal DNA and application thereof
US11242520B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Jul 23, 2019 |
| Grant date | Feb 8, 2022 |
| Priority date | — |
| Expiry date | Mar 22, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N35/0098
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided is a method for isolating exosomal DNA, the method comprising: (i) providing a sample, wherein the sample comprises a blood sample from peripheral blood of a pregnant woman; and (ii) subjecting the sample to isolating, thus obtaining the exosomal DNA. Also provided are a method for detecting a blood sample, a method for constructing a sequencing library on a blood sample, a method for high-throughput sequencing an exosomal DNA sequencing library, a method for non-invasive prenatal gene detection, a device for non-invasive prenatal gene detection, and a kit for detecting a blood sample and use thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.