Corynebacterium for producing L-lysine by fermentation
US11242545B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Jan 9, 2017 |
| Grant date | Feb 8, 2022 |
| Priority date | — |
| Expiry date | Sep 5, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/15
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for producing L-lysine by fermentation, comprising modifying a gene for coding an NCBI reference sequence NP_601029.1 and/or NP_599350.1 on a Corynebacterium bacterial chromosome to enable the activity and/or expression quantity of NP_601029.1 and/or NP_599350.1 to be reduced; replacing a promoter of one or more genes on the Corynebacterium bacterial chromosome with a EP5 promoter, and fermenting bacteria obtained by modification to produce L-lysine. Also provided are methods and applications derived from the method, and bacteria and promoter that can used in the methods and the applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.