Eukaryotic cells and methods for recombinantly expressing a product of interest

US11242551B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Thomas Jostock · Neuenburg am Rhein, DE
• Holger Laux · Irslingen, DE
• Anett RITTER · Weil am Rhein, DE

Key dates

• Filing date: Dec 18, 2014
• Grant date: Feb 8, 2022
• Expiry date: Feb 2, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the genome of the host cell is altered so that the effect of protein FAM60A is impaired in said cell, e.g. by reducing or eliminating functional expression of gene FAM60A thereby improving the stability characteristics. Furthermore, the present disclosure provides associated technologies wherein such host cells are used in recombinant production technologies.