Integrated closed-loop medication delivery with error model and safety check
US11246986B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 18, 2019 |
| Grant date | Feb 15, 2022 |
| Priority date | — |
| Expiry date | Oct 18, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2230/201
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.