Patent · US Active

Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases

US11247972B2 · kind B2 · utility

0Cited by

0References

22Claims

0Family size

Assignee

University of Washington through its Center for Commercialization · US

Inventors

Wesley C. Van Voorhis · Seattle, US
Wilhelmus G.J. Hol · Kenmore, US
Eric T. Larson · Bethel, US
Dustin J. Maly · Seattle, US
Ethan Merritt · Seattle, US
Kayode K. Ojo · Federal Way, US

Key dates

Filing date	Jan 10, 2020
Grant date	Feb 15, 2022
Priority date	—
Expiry date	Apr 25, 2040

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula,

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.