Inhibitors of MALT1 and uses thereof

US11248007B2 · kind B2 · utility

Assignees

• Cornell University · IT
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Nathanael S. Gray · Boston, US
• David A. Scott · Newton, US
• John Hatcher · Boston, US
• Ari M. Melnick · New York, US
• Lorena Fontan Gabas · New York, US

Key dates

• Filing date: Mar 8, 2018
• Grant date: Feb 15, 2022
• Expiry date: Mar 8, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are compounds that inhibit MALT1, a protein whose activity is responsible for constitutive NF-κB signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating MALT1-related diseases and disorders (e.g., cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.