Mutant tumor necrosis factor receptor superfamily (TNFsfR) ligands and methods of making and using same
US11248036B2 · kind B2 · utility
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Key dates
| Filing date | Dec 17, 2019 |
| Grant date | Feb 15, 2022 |
| Priority date | — |
| Expiry date | Dec 17, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF superfamily receptors while failing to engage or inhibit non-target TNF superfamily receptors, and methods of their use to treat diseases are provided. Single chain RANKL, TNF, and TRAIL ligands that effectively inhibit their target receptors while failing to inhibit non-target TNF superfamily receptors are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.