Magnetic resonance method for detecting molecular binding with enhanced sensitivity
US11249161B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 2, 2018 |
| Grant date | Feb 15, 2022 |
| Priority date | — |
| Expiry date | Feb 15, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/5608
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method to detect transient binding of a substrate molecule of interest in solution to a molecular target includes selecting the substrate molecule of interest and the molecular target such that the substrate molecule of interest can transiently bind to the molecular target; placing one of a sample or a subject of interest in a magnetic resonance (MR) apparatus, the sample or the subject of interest containing the substrate molecule of interest so as to be in contact with the molecular target; providing magnetic labelling of non-exchangeable or slowly exchangeable MR sensitive nuclei of the substrate molecule of interest; receiving an MR signal from the MR sensitive nuclei of the solvent molecules using the MR apparatus; and analyzing the MR signal to obtain a quantity associated with the transient binding of the substrate molecule of interest to the molecular target.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.