Patent · US Active

Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases

US11253526B2 · kind B2 · utility

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3Claims

0Family size

Assignee

DISTRETTO TECNOLOGICO SICLILIA MICRO E NANO SISTEMI S.C.A.R.L. · IT

Inventors

Anna Rita Blanco · Loreto, IT
Maria Luisa Bondi′ · Trabia, IT
Gennara Cavallaro · Palermo, IT
Grazia Maria Letizia Consoli · Valverde, IT
Emanuela Fabiola Craparo · Palermo, IT
Gaetano Giammona · Palermo, IT
Mariano Licciardi · Palermo, IT
Giovanna Pitarresi · Palermo, IT
Guiseppe Granata · Loreto, IT
Patrizia Saladino · Santa Ninfa, IT
Clara La Marca · Canicattì, IT
Irene Deidda · Palermo, IT
Salvatore Papasergi · Taurianova, IT
Patrizia Guarneri · Palermo, IT
Salvatore Cuzzocrea · Trecastagni, IT
Emanuela Esposito · Napoli, IT
Santa Viola · Potenza, IT

Key dates

Filing date	Aug 3, 2020
Grant date	Feb 22, 2022
Priority date	—
Expiry date	Aug 3, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2603/92
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.