CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
US11253547B2 · kind B2 · utility
6Cited by
66References
19Claims
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Assignee
Inventors
Key dates
| Filing date | Nov 4, 2020 |
| Grant date | Feb 22, 2022 |
| Priority date | — |
| Expiry date | Nov 4, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.
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