Compositions and methods for inducing immune tolerance

US11253579B2 · kind B2 · utility

Assignees

• THE UNIVERSITY OF CHICAGO · US
• Anokion SA · CH

Inventors

• Jeffrey A. Hubbell · Austin, US
• David Scott Wilson · Redwood City, US
• Kristen Marie Lorentz · Cambridge, US
• Stephan Kontos · Lausanne, CH

Key dates

• Filing date: Jun 14, 2018
• Grant date: Feb 22, 2022
• Expiry date: Jun 14, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/627
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Several embodiments provided in the present disclosure relate to compositions that carry an antigen to which tolerance is desired, the antigen being coupled, bound, or otherwise joined to a targeting moiety, the targeting moiety configured to direct the composition to the liver of a subject. In several embodiments, the antigen in coupled to the targeting moiety by way of a polymeric linker. In several embodiments, the polymeric linker is configured to liberate the antigen in vivo. Methods of using the compositions to reduce and/or prevent unwanted immune responses against an antigen of interest are also provided.