Water-soluble compounds with aggregation-induced emission characteristics
US11253592B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Oct 24, 2018 |
| Grant date | Feb 22, 2022 |
| Priority date | — |
| Expiry date | Nov 27, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09K2211/1092
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present subject matter relates to water-soluble, fluorescent compounds that have aggregation-induced emission (AIE) characteristics and exhibit near infrared (NIR) absorption. The compounds can be utilized as plasma-membrane specific bio-probes in cell imaging through a wash-free and fast staining procedure. In addition, the compounds can efficiently generate reactive oxygen species (ROS) in vivo when irradiated with visible light. As such, the compounds can be effective in killing cancer cells through image-guided, photodynamic therapy (PDT) processes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.