Analgesic preparation with nanocarriers and use thereof

US11253599B2 · kind B2 · utility

Assignee

• DendroPharm GmbH · DE

Inventors

• Emanuel Fleige · Berlin, DE
• Sam Moré · Dresden, DE
• Michael Unbehauen · Berlin, DE
• Rainer Haag · Berlin, DE
• Christoph Stein · Baltimore, US
• Halina Machelska-Stein · Berlin, DE
• Florian Paulus · Berlin, DE

Key dates

• Filing date: Dec 8, 2016
• Grant date: Feb 22, 2022
• Expiry date: Dec 8, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2300/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.