NLRP3 inflammasome inhibitors
US11254653B2 · kind B2 · utility
11Cited by
3References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 15, 2020 |
| Grant date | Feb 22, 2022 |
| Priority date | — |
| Expiry date | May 15, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D451/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.