Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide

US11254679B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Burcu Selin Aytar · Sparta, US
• Alina Borovika · Brooklyn, US
• Collin Chan · New York, US
• Joerg Deerberg · Columbus, US
• Nathan R. Domagalski · Niantic, US
• Martin D. Eastgate · Titusville, US
• Yu Fan · Taipei, TW
• Michael David Bengt Fenster · New York, US
• Robert V. Forest · Fryeburg, US
• Francisco Gonzalez-Bobes · New Brunswick, US
• Rebecca A. Green · Metuchen, US
• Matthew R. Hickey · New Brunswick, US
• Nathaniel David Kopp · Newtown, US
• Thomas E. La Cruz · New Brunswick, US
• Kathleen Lauser · Minneapolis, US
• Hong Geun Lee · Seoul, KR
• David K. Leahy · Somerville, US
• Helen Y. Luo · San Francisco, US
• Thomas M. Razler · Yardley, US
• Scott A. Savage · Yardley, US
• Chris Sfouggatakis · Staten Island, US
• Maxime C. Soumeillant · Hamilton Square, US
• Serge Zaretsky · Fords, US
• Bin Zheng · Kendall Park, US
• Ye Zhu · Singapore, SG

Key dates

• Filing date: Jul 19, 2018
• Grant date: Feb 22, 2022
• Expiry date: Jul 19, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide,