Patent · US Active

Antimicrobial peptide Sparamosin from Scylla paramamosain and application thereof

US11254717B2 · kind B2 · utility

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0References

7Claims

0Family size

Assignee

XIAMEN UNIVERSITY · CN

Inventors

Kejian Wang · Zhejiang, CN
Yanchao CHEN · Fujian, CN
Fangyi Chen · Xiamen, CN
Ying Yang · Monmouth Junction, US
Hui Peng · Miaocheng, CN
Huiyun Chen · Fujian, CN

Key dates

Filing date	Jul 31, 2020
Grant date	Feb 22, 2022
Priority date	—
Expiry date	Jul 31, 2040

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided is an antimicrobial peptide Sparamosin from Scylla paramamosain. The Sparamosin mature peptide and its functional domain Sparamosin26-54 were synthesized by solid-phase synthesis with a purity of over 95%. Both Sparamosin and Sparamosin26-54 exhibit strong antimicrobial activity. More importantly, Sparamosin26-54 has strong antifungal activity and could inhibit the growth of a variety of yeasts and filamentous fungi. Based on the potent antimicrobial activities of Sparamosin and Sparamosin26-54, both peptides could be developed as alternatives for conventional antibiotics, antimicrobial agents, feed additives in aquaculture and livestock, preservatives, and mold inhibitors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.