Patent · US Active

Fab molecules with a rodent hinge region and a non-rodent CH1 region

US11254734B2 · kind B2 · utility

0Cited by

1References

7Claims

0Family size

Assignee

MORPHOSYS AG · DE

Inventors

Julia Neugebauer · Munich, DE
Steffen Runz · Heidelberg, DE
Stefanie Urlinger · Munich, DE

Key dates

Filing date	Nov 13, 2017
Grant date	Feb 22, 2022
Priority date	—
Expiry date	Jan 31, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/55
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The disclosure relates to novel Fab molecules comprising a modified heavy chain constant region. The modified constant region prevents the recognition of the Fab molecules by anti-Fab antibodies present in a host's serum. The disclosure further relates to methods of generating such modified Fab molecules for biological, diagnostic, pharmaceutical and other uses.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.