Patent · US Active

Transcriptional regulatory element and its use in enhancing the expression of heterologous protein

US11254952B2 · kind B2 · utility

0Cited by

1References

20Claims

0Family size

Assignee

WUXI BIOLOGICS IRELAND LIMITED · IE

Inventors

Zheng Zhang · Beijing, CN
Xiaolu Li · San Francisco, US
Yuchen Zhang · Tianjin, CN
Yarong Li · Shanghai, CN
Huifang Dong · Shanghai, CN
Jill Cai · Shanghai, CN
Weichang Zhou · Framingham, US
Chris Chen · Media, US
Lili Mu · Shanghai, CN
Chuanlong Tang · Shanghai, CN

Key dates

Filing date	Aug 14, 2019
Grant date	Feb 22, 2022
Priority date	—
Expiry date	Aug 14, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2840/105
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Provided is a polynucleotide, the polynucleotide can be used as a WXRE transcriptional regulatory element used to increase the protein expression level of a protein expression system. A protein expression vector or a protein expression system comprising the above-mentioned WXRE transcriptional regulatory element as well as the use thereof are also provided. The use of the WXRE transcriptional regulatory element can increase the expression level of a heterologous protein greatly with its biological activity unchanged.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.