Nanosome formulations of aprepitant and methods and applications thereof

US11260028B2 · kind B2 · utility

Assignee

• FORDOZ PHARMA CORP. · US

Inventors

• Sydney Ugwu · Gurnee, US
• Xin He · Greenville, US
• Zengli Fu · Kendall Park, US
• Xin Teng · Framingham, US
• Ming Ji · Beijing, CN

Key dates

• Filing date: Jun 26, 2018
• Grant date: Mar 1, 2022
• Expiry date: Jun 26, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are pharmaceutical formulations of aprepitant suitable for parenteral administration including intravenous administration. The pharmaceutical formulations are stable and ready-to-use liposomes for the treatment of emesis and are particularly useful for treatment of chemotherapy or surgery-induced nausea and vomiting. Methods of preparation of the aprepitant formulations are also provided.