Protein particle with a poorly water-soluble drug encapsulated therein and preparation method thereof

US11260031B2 · kind B2 · utility

Assignee

• Academy of Military Medical Sciences · CN

Inventors

• Zhiping Li · Qingdao, CN
• Zhenbo Yang · Hangzhou City, CN
• Yang Yang · Parsippany, US
• Fanglin Yu · Beijing, CN
• Wei Gong · Burnaby, CA
• Meiyan Yang · Beijing, CN
• Yuli Wang · Tianjin, CN
• Chunsheng Gao · Beijing, CN
• Xingguo Mei · Beijing, CN

Key dates

• Filing date: Apr 26, 2018
• Grant date: Mar 1, 2022
• Expiry date: Apr 26, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a protein particle with a poorly water-soluble drug encapsulated therein and a preparation method therefor. The preparation method comprises the following steps: i) dissolving a poorly water-soluble drug and a liquid solubilizer into a good solvent; ii) partially or fully removing said good solvent from the product of step i); iii) mixing the product of step ii) with a protein; and iv) dispersing the product of step iii) in a poor solvent. The preparation method is simple and is suitable for industrial production.