Compounds for use as iron(III) MRI contrast agents

US11261208B2 · kind B2 · utility

Assignee

• The Research Foundation for The State University of New York · US

Inventors

• Janet R. Morrow · Williamsville, US
• Eric M. SNYDER · Williamsville, US
• Didar ASIK · Buffalo, US

Key dates

• Filing date: May 21, 2018
• Grant date: Mar 1, 2022
• Expiry date: May 21, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are macrocyclic compounds and compounds with two or more macrocyclic groups, iron coordinated macrocyclic compounds, and iron coordinated compounds with two or more macrocyclic groups. The iron is high-spin iron(III). The iron coordinated compounds may exhibit a negative redox potential (e.g., relative to a normal hydrogen electrode at a biologically relevant pH, for example, a pH of 6.5-7.5). The compounds can be used as MRI contrast agents.