Bi-specific molecule for cell-specific Notch inhibition and related methods and compositions
US11261250B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 20, 2017 |
| Grant date | Mar 1, 2022 |
| Priority date | — |
| Expiry date | Mar 5, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This disclosure provides compositions and related methods providing targeted cell-specific inhibition of Notch receptor signaling. The disclosure provides a bi-specific molecule with separate domains that target the intended cell-type and the Notch receptor on that cell-type. The disclosure also provides for nucleic acids, vectors, and cells allowing for the expression of the bi-specific fusion molecules. The disclosure also provides related methods of making and using the bi-specific fusion molecule to inhibit Notch signaling in target cells of interest, including for the treatment of diseases characterized by a dysregulation of Notch signaling.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.