Mevalonate diphosphate decarboxylase variants
US11261438B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 9, 2014 |
| Grant date | Mar 1, 2022 |
| Priority date | — |
| Expiry date | Dec 20, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y401/01033
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described are mevalonate diphosphate decarboxylase variants having improved activity in converting 3-phosphonoxyisovalerate into isobutene. Such variants can be employed in processes for biologically producing isobutene from 3-hydroxyisovalerate or from 3-hydroxy-3-methylbutyrate into isobutene, for biologically producing isoprenol from mevalonate or from mevalonate-3-phosphate or for biologically producing 1,3-butadiene from 3-hydroxypent-4-enoate or from 3-phosphonoxypent-4-enoate.Also described is an enzyme which is characterized in that it is capable of converting 3-phosphonoxyisovalerate into isobutene with a kcat of more than 0.1 s−1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.