Thermal stable luciferase with improved resistance to inhibition by luciferin break-down products
US11261478B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Oct 13, 2017 |
| Grant date | Mar 1, 2022 |
| Priority date | — |
| Expiry date | Feb 5, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y113/12007
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are inhibitor-resistant luciferase mutants, and methods of use thereof. In particular, luciferase mutants are provided that are thermal stable and exhibit improved stability in the presence of luciferin break-down products, such as dehydroluciferin. Further provided are assay systems comprising inhibitor-resistant luciferase mutants and amino acid sequences of the inhibitor-resistant luciferase mutants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.