Membrane layers for analyte sensors

US11262326B2 · kind B2 · utility

Assignee

• Dexcom, Inc. · US

Inventors

• Shanger Wang · Castro Valley, US
• Robert J. Boock · Carlsbad, US
• Andrew Trinin Dennis · Village of La Jolla, US
• Ted Tang Lee · San Diego, US
• Jeff T. Suri · Fallbrook, US
• David Sze · San Diego, US
• Mark A. Tapsak · Bloomsburg, US
• Huashi Zhang · San Diego, US
• Jiong Zou · San Diego, US

Key dates

• Filing date: Dec 30, 2016
• Grant date: Mar 1, 2022
• Expiry date: May 17, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/3275
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.