Beta-hydroxybutyrate encapsulated PLGA nanoparticle compositions
US11266617B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Oct 16, 2019 |
| Grant date | Mar 8, 2022 |
| Priority date | — |
| Expiry date | Jan 29, 2040 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions comprising β-hydroxybutyrate, cyclic or linear β-hydroxybutyrate oligomers, and/or β-hydroxybutyrate ester derivatives, or pharmaceutically-acceptable salts thereof. In various embodiments, the compositions are encapsulated by nanoparticles, such as nanoparticles comprising, e.g., poly(lactic-co-glycolic acid). In additional embodiments, the invention provides methods of using such compositions to induce intestinal stem cell regeneration and/or treat radiation-induced intestinal damage in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.