Engineered FGF1 and FGF2 compositions and methods of use thereof

US11267855B2 · kind B2 · utility

Assignee

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US

Inventors

• Suresh Kumar Thallapuranam · Fayetteville, US
• Shilpi Agarwal · Bengaluru, IN
• Ravi K. Gundampati · Fayetteville, US
• Srinivas Jayanthi · Fayetteville, US
• Tengjiao Wang · Fayetteville, US
• Jake D. Jones · Fayetteville, US
• Olivia Kolenc · Fayetteville, US
• Ngoc Lam · Fayetteville, US
• Isabelle Niyonshuti · Fayetteville, US
• Kartik Balachandran · Fayetteville, US
• Kyle Quinn · Fayetteville, US
• Jingyi Chen · Fayetteville, US

Key dates

• Filing date: Mar 18, 2019
• Grant date: Mar 8, 2022
• Expiry date: Mar 18, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.