Anti-PD-L1 antibody and application thereof

US11267890B2 · kind B2 · utility

Assignees

• SHANGHAI JUNSHI BIOSCIENCES CO., LTD · CN
• Suzhou Junmeng Biosciences Co., Ltd. · CN

Inventors

• Hai Wu · Palo Alto, US
• Sheng Yao · Columbia, US
• Yuehua ZHOU · 安丰镇, CN
• Jian Yao · Shanghai, CN
• Dan Meng · 安丰镇, CN
• Hui Feng · Daxi District, TW

Key dates

• Filing date: Feb 13, 2018
• Grant date: Mar 8, 2022
• Expiry date: May 28, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An antibody or a functional fragment thereof that specifically bind to PD-L1 with high affinity, a nucleic acid molecule that encodes said antibody or the functional fragment thereof, an expression vector and a host cell for use in expressing said antibody or the functional fragment thereof, and a method for producing said antibody or the functional fragment thereof. An immunoconjugate and a pharmaceutical composition containing said antibody or the functional fragment thereof, and a method for using said antibody or the functional fragment thereof to enhance the function of a T cell so as to up-regulate a cell-mediated immune response, for use in treating diseases caused by T cell dysfunction.