Reprogramming methods and cell culture platforms
US11268069B2 · kind B2 · utility
3Cited by
52References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 4, 2015 |
| Grant date | Mar 8, 2022 |
| Priority date | — |
| Expiry date | Apr 11, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15043
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides compositions and methods for manufacturing pluripotent cells. In particular, the invention provides improved culture platforms for manufacturing pluripotent cells with ground state pluripotency. In various embodiments, the invention contemplates, in part, a composition comprising: (a) a Wnt pathway agonist; (b) a MEK inhibitor; and (c) a ROCK inhibitor. In certain embodiments, the composition further comprises bFGF or LIF.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.