Identification of transglutaminase substrates and uses therefor

US11268120B2 · kind B2 · utility

Assignee

• Roche Sequencing Solutions, Inc. · US

Inventors

• Thomas Albert · Danville, US
• Frank Bergmann · Iffeldorf, DE
• Victor Lyamichev · Madison, US
• Jigar Patel · London, GB
• Michael Schraeml · Penzberg, DE
• Wojtek Steffen · Rosenheim, DE

Key dates

• Filing date: Jun 16, 2017
• Grant date: Mar 8, 2022
• Expiry date: Jun 16, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/21
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

According to one aspect, the present disclosure provides a method of identifying a substrate of a transglutaminase using a peptide array comprising a plurality of peptides. The method includes the steps of contacting the peptides in the peptide array with the transglutaminase, allowing the transglutaminase to bind to the peptides, and identifying the substrate of the transglutaminase.