Genetically modified non-human animal with human or chimeric PD-1
US11272695B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jun 10, 2019 |
| Grant date | Mar 15, 2022 |
| Priority date | — |
| Expiry date | Jun 10, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.