Biologically applicable water-soluble heterogeneous catalysts for para-hydrogen induced polarization

US11273431B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• Cedars Sinai Medical Center · US

Inventors

• Louis Bouchard · Los Angeles, US
• Shawn Wagner · Altadena, US
• Stefan Gloeggler · Bordeaux, FR

Key dates

• Filing date: Oct 31, 2017
• Grant date: Mar 15, 2022
• Expiry date: Oct 31, 2037

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2531/828
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A heterogeneous catalyst composition for para-hydrogen induced polarization includes ligand-capped nanoparticles dispersed in water. The ligand-capped nanoparticles include metal nanoparticles that are surface functionalized with organic ligands, a molecular weight of the organic ligands is no greater than 300 g/mol, and the organic ligands each includes multiple binding moieties as coordinates sites for binding to a nanoparticle surface.