Optical detection based on non-linear magnetophoretic transport of magnetic particle for particle and biological sensing and separation
US11273454B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 4, 2016 |
| Grant date | Mar 15, 2022 |
| Priority date | — |
| Expiry date | Oct 2, 2037 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB03C2201/26
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
There is provided system and a separation substrate device for use with an NLM separator in separating and/or detecting at least one target analyte in a sample, the substrate comprising a micromagnet array of a plurality of micromagnets, the micromagnet array comprising a first capture region, a second focusing region, and, a third detection region, the focusing region comprising a converging and/or diverging micromagnet array region. Also provided is a method for separating and detecting at least one target analyte in a sample. The method including: contacting a plurality of magnetic beads with a sample, the magnetic beads functionalized for binding with one or more target analytes in a sample to form aggregates; providing the sample including magnetic beads and aggregates to a separating substrate comprising a micromagnet array of a plurality of micromagnets; transporting the magnetic beads and aggregates relative to the micromagnet array to provide separation and enable detection of the magnetic beads and aggregates; detecting motion of the beads or aggregates of the sample on the array in response to the applied magnetic field and/or detecting beads or aggregates of the sample …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.