Processes and intermediates for the preparation of soluble guanylate cyclase stimulators
US11274096B2 · kind B2 · utility
2Cited by
1References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 10, 2019 |
| Grant date | Mar 15, 2022 |
| Priority date | — |
| Expiry date | Jan 10, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as simulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said simulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.