Patent · US Active

Methods, kits and apparatus for expanding a population of cells

US11274278B2 · kind B2 · utility

5Cited by

16References

38Claims

0Family size

Assignee

Juno Therapeutics, Inc. · US

Inventors

Lothar GERMEROTH · Oettingen, DE
Christian STEMBERGER · Holzkirchen, DE

Key dates

Filing date	Apr 16, 2015
Grant date	Mar 15, 2022
Priority date	—
Expiry date	Apr 28, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/03
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to in vitro-methods of expanding a population of cells such as lymphocytes, comprising contacting a sample comprising a population of cells with a multimerization reagent. The multimerization reagent has reversibly immobilized thereon (bound thereto) a first agent that provides a primary activation signal to the cells and optionally, a second agent that provides a co-stimulatory signal. The invention also provides multimerization reagents, kits, arrangements and an apparatus for expanding cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.