High concentration alpha-glucosidase compositions for the treatment of Pompe disease
US11278599B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Sep 24, 2019 |
| Grant date | Mar 22, 2022 |
| Priority date | — |
| Expiry date | Dec 28, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y302/0102
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application provides for compositions comprising high concentrations of acid a-glucosidase in combination with an active site-specific chaperone for the acid α-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid α-glucosidase enzyme formulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.