Enantiomeric separation of racemic nicotine by addition of an O,O″-disubstituted tartaric acid enantiomer
US11279685B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Dec 18, 2018 |
| Grant date | Mar 22, 2022 |
| Priority date | — |
| Expiry date | Dec 18, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a method of separating racemic nicotine of Formula (1-a) as a mixture of the (R)- and (S)-enantiomers into the enantiomerically pure (S)- and (R)-nicotine represented by Formula (1-b) and (1-c), by adding a mixture of the L- and the D-enantiomer of a O,O′-disubstituted tartaric acid, wherein the molar ratio of the L- to the D-enantiomer is from 80:20 to 95:5, and obtaining the (S)-nicotine of formula (1-b), or by adding O,O′-dibenzoyl-D-tartaric acid and obtaining the (R)-nicotine of formula (1-c).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.