Devices and methods related to airway inflammation
US11280783B2 · kind B2 · utility
Assignees
Inventor
Key dates
| Filing date | Apr 29, 2020 |
| Grant date | Mar 22, 2022 |
| Priority date | — |
| Expiry date | Apr 29, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7052
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This disclosure relates to devices, assays, and methods related to airway inflammation caused by polymorphonuclear neutrophils (PMNs). In certain embodiments, the disclosure relates to a model device that emulates the changes in airway cell physiology due to transmigration of PMNs from blood to the cells at the air-liquid interface. In certain embodiments, the airway cells are supported on a collagen layer wherein the collagen layer is further supported by a porous polymer from which PMNs can migrate. In certain embodiments, the disclosure contemplates adding bacteria, fungi and/or viruses to the device to emulate disease states. In certain embodiments, the disclosure relates to the use of the model system to test compounds to identify drug candidates and diagnose subjects with airway-related diseases and conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.