2- or 3-imidazolines as carbapenemases inhibitors
US11285133B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Mar 8, 2018 |
| Grant date | Mar 29, 2022 |
| Priority date | — |
| Expiry date | Aug 22, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application relates to novel 3-imidazolines of formula (I′) and (I) below: (I′) (I) Wherein Ar1, Ar2, Ar3, and R1 to R6 are as defined in the claims. The 3-imidazolines of the invention are useful in antibiotic therapies, in particular as inhibitors of carbapenemases. They are also useful as antibiotics themselves. The present invention also concerns a method for preparing more specifically the 3-imidazolines of formula (I). The present invention further relates to conjugates of said compounds with known antibiotics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.