Compositions and methods for treating CDK4/6-mediated cancer

US11285150B2 · kind B2 · utility

Assignee

• ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · US

Inventors

• Jian Jin · Suzhou, CN
• Xiaobao Yang · New York, US
• Jing Liu · San Diego, US
• Yan Xiong · New York, US
• Poulikos Poulikakos · New York, US
• Zoi Karoulia · New York, US
• Xuewei Wu · Beijing, CN
• Tamer Ahmed · Edison, US

Key dates

• Filing date: Dec 7, 2017
• Grant date: Mar 29, 2022
• Expiry date: Dec 7, 2037

Classification

• Technology area (CPC —): General

Abstract

Methods for designing heterobifunctional small molecules which selectively degrade/disrupt CDK4/6 and compositions and methods of using such degraders/disruptors to treat CDK4/6-mediated cancer are provided.