Melatonin derivatives, method thereof, and use thereof
US11286238B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 16, 2020 |
| Grant date | Mar 29, 2022 |
| Priority date | — |
| Expiry date | Apr 16, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure discloses melatonin derivatives, a method thereof, and a use thereof. The method comprises: dissolving melatonin in a solvent, adding a catalyst while maintaining the solvent at 0° C. to obtain a first reaction solution, stirring the first reaction solution, adding reactants in the first reaction solution, continually stirring at room temperature or at refluxing reaction temperature until, when analyzing by thin layer chromatography, the first reaction solution is fully reacted, quenching the reaction with ice water, concentrating the first reaction solution to obtain a residue of the first reaction solution, and purifying the residue of the first reaction solution by column chromatography to obtain the melatonin derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.